DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis
نویسندگان
چکیده
منابع مشابه
Genetic polymorphism of melatonin receptor 1A (MTNR1A) gene in Corriedale sheep of Kashmir, India
The aim of the present work was to explore and characterize the different polymorphic variants of exon II region of MTNR1A gene in 31Corriedale sheep of Kashmir. Genomic DNA was extracted and subjected to PCR for the amplification of the main part of exon II of the ovine MTNR1A gene. PCR products were subjected to restriction enzyme (RE) digestion by MnlI restriction enzyme and depending upon n...
متن کاملMapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and cattle.
and Implications Human and sheep Melatonin receptor 1a (MTNR1A) gene information was used to clone a portion of the coding region of this gene in pigs, and to identify polymorphisms of the gene for its assignment to both the genetic linkage and physical maps. MTNR1A maps to pig chromosome 17, establishing a new region of conserved synteny between this chromosome and human chromosome 4. Furtherm...
متن کاملThe melatonin receptor 1A (MTNR1A) gene is associated with recurrent and idiopathic calcium nephrolithiasis.
BACKGROUND Experimental evidence indicate that melatonin regulates some renal tubular functions via specific melatonin receptors (MTNRs) located in the kidney of several avian and mammalian species, including humans. We hypothesized that single nucleotide polymorphisms (SNPs) in the melatonin receptor 1A gene (MTNR1A) might influence the risk of calcium nephrolithiasis. METHODS We performed a...
متن کاملGenetic Polymorphism of the Melatonin Receptor 1A Locus in Iranian Shall and Karakul Sheep
The genotypes of the melatonin receptor 1A (MTNR1A) were determined by PCR-RFLP in the native Iranian Shall and karakul breeds of sheep . Blood samples were collected from 60 karakul and 50 Shall breeds. Genomic DNA was extracted based on the Guanidin Thiocyanate-slica gel method. After PCR reaction, PCR products were digested by the Mnl1 restriction enzyme. The MTNR1A locus had two genotypes ...
متن کاملPaternally transmitted parasites
of survival curves and that I am a bit skeptical of science being intrinsically a young woman's or man's game. When we ultimately understand the neurobiological basis of creativity in science, I doubt that we will have a cellular mechanism-based affirmation of that frequently made assertion about the primacy of youth (which is most frequently heard from no-longer young researchers-turned-admini...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2016
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2015.12.1341